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David Heimbrook Selected Research

(2S,3S)- 2- ((R)- 4- (4- (2- hydroxyethoxy)phenyl)- 2,5- dioxo- imidazolidin- 1- yl)- 3- phenyl- N- (4- propionylthiazol- 2- yl)butyramide

3/2009Characterization of a novel mitogen-activated protein kinase kinase 1/2 inhibitor with a unique mechanism of action for cancer therapy.

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David Heimbrook Research Topics

Disease

14Neoplasms (Cancer)
07/2014 - 01/2004
3Colorectal Neoplasms (Colorectal Cancer)
02/2012 - 01/2009
2Melanoma (Melanoma, Malignant)
02/2012 - 07/2010
1Osteosarcoma (Osteogenic Sarcoma)
07/2014
1Colonic Neoplasms (Colon Cancer)
08/2011
1Breast Neoplasms (Breast Cancer)
07/2007
1Adenocarcinoma
07/2007

Drug/Important Bio-Agent (IBA)

5Phosphotransferases (Kinase)IBA
08/2011 - 01/2004
3VemurafenibIBA
02/2012 - 07/2010
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
02/2012 - 03/2009
3Bevacizumab (Avastin)FDA Link
01/2009 - 07/2007
3Capecitabine (Xeloda)FDA Link
01/2009 - 07/2007
2Codon (Codons)IBA
02/2012 - 07/2010
2Amyloid Precursor Protein Secretases (beta-Secretase)IBA
06/2011 - 10/2009
22,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA
06/2011 - 10/2009
2Mitogen-Activated Protein KinasesIBA
01/2010 - 03/2009
1RG7388IBA
07/2014
1Interleukin-6 (Interleukin 6)IBA
06/2011
1Interleukin-8 (Interleukin 8)IBA
06/2011
1Proteins (Proteins, Gene)FDA Link
07/2010
1MitogensIBA
07/2010
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
07/2010
12- (4- (4- (2,3- dihydroxy- propoxy)phenyl)- 2,5- dioxo- imidazolidin- 1- yl)- N- (2- fluoro- 4- iodo- phenyl)- 3- phenylbutyramideIBA
01/2010
1Pharmaceutical PreparationsIBA
01/2010
1(2S,3S)- 2- ((R)- 4- (4- (2- hydroxyethoxy)phenyl)- 2,5- dioxo- imidazolidin- 1- yl)- 3- phenyl- N- (4- propionylthiazol- 2- yl)butyramideIBA
03/2009
1MAP Kinase Kinase 1IBA
03/2009
1Irinotecan (Camptosar)FDA LinkGeneric
01/2009
1Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2009
1AgarIBA
02/2008
1Small Interfering RNA (siRNA)IBA
02/2008
1Antineoplastic Agents (Antineoplastics)IBA
02/2008
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
02/2008
1Estrogen ReceptorsIBA
07/2007
1AnthracyclinesIBA
07/2007
1Taxoids (Taxanes)IBA
07/2007
1Retinoblastoma ProteinIBA
11/2006
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2004
1Tyrosine (L-Tyrosine)FDA Link
01/2004

Therapy/Procedure

2Therapeutics
06/2011 - 03/2009